Spasmolytic Polypeptide Expressing Metaplasia
Numerous studies have implicated intestinal metaplasia as a useful biomarker for gastric cancer risk and even possibly a precursor to gastric malignancy.
Spasmolytic polypeptide expressing metaplasia. Felis infected mice sachiyo nomura tammy baxter hirokazu yamaguchi charles leys andrey b. Other investigations of intestinal progenitor cells have shown that cells demonstrating. 16 x 16 yoshizawa n takenaka y yamaguchi h. Time for reevaluation of metaplasias and the origins of gastric cancer gastroenterology.
1 nashville va medical center and the department of surgery vanderbilt university school of medicine nashville tennessee 37232 2733 usa. Spasmolytic polypeptide expressing metaplasia and intestinal metaplasia. Spasmolytic polypeptide tff2 expressing metaplasia spem is observed in mucosa adjacent to human gastric cancer and in fundic glands showing oxyntic atrophy in helicobacter felis infected mice. Wang and james r.
Spasmolytic polypeptide expressing metaplasia spem in the gastric oxyntic mucosa does not arise from lgr5 expressing cells. Objective metaplastic lineages in the oxyntic mucosa of the stomach are critical preneoplastic precursors of gastric cancer. Emergence of spasmolytic polypeptide expressing metaplasia in mongolian gerbils infected with helicobacter pylori. Other investigations of intestinal progenitor cells have shown that cells demonstrating transcriptional activity for lgr5 in the intestine colon and gastric antrum function as adult stem cells.
Goldenring jr nam kt wang tc mills jc wright na. The goal of these studies was to define the transcriptional changes associated with spem at the individual cell level in response to acute drug injury and chronic. Mongolian gerbils develop both spem and intestinal metaplasia in the fundus after infection with h pylori. Nam kt 1 o neal rl coffey rj finke pe barker n goldenring jr.
Recent studies have demonstrated that spasmolytic polypeptide expressing metaplasia spem in the mouse oxyntic mucosa arises from transdifferentiation of mature gastric chief cells. Spasmolytic polypeptide expressing metaplasia and intestinal metaplasia. Goldenring nashville va medical center and the department of surgery vanderbilt ingram cancer center vanderbilt university school of. Spasmolytic polypeptide expressing metaplasia spem is a preneoplastic gastric cancer lesion related to epigenetic microrna mirna expression.
Objective spasmolytic polypeptide expressing metaplasia spem is a regenerative lesion in the gastric mucosa and is a potential precursor to intestinal metaplasia gastric adenocarcinoma in a chronic inflammatory setting. Recent studies have demonstrated that spasmolytic polypeptide expressing metaplasia spem in the mouse oxyntic mucosa arises from transdifferentiation of mature gastric chief cells.
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